How a Bacillus “Sees” the World: Information Needs and Signaling Resources of Mycobacterium Tuberculosis

  • Jorge Navarro
  • Pedro C. Marijuán
Keywords: Mycobacterium tuberculosis, transcriptional regulatory network, signaling system, information and meaning, knowledge recombination


Any living cell parasitizing a host organism is immersed into a molecular environment of unfathomable complex- ity. For the advancement of its life cycle in such “hostile” a territory, the cell has to carefully sense its environment, “see” the ongoing physiological processes taking place, and guide subsequently its own network of self-construction processes, pathological responses included. We will discuss how this informational matching occurs in the bacillus Mycobacterium tuberculosis, and how transcriptional programs within the global transcriptional regulatory network are deployed in response to specific signals from the environment and from within the cell itself. In the era of the bioinformatic revolution and of sys- tems biology, it is perhaps surprising that the functional interconnection between the transcription network and the signaling system is far from clarified yet. In the extent to which the living cell can be considered as one of the central paradigms of the nascent information science, this discussion also becomes one about the essential cluster of concepts which should poten- tially apply to the analysis of other information-based entities.

Author Biographies

Jorge Navarro
Jorge Navarro López Chemical Engineer, Universidad de Zaragoza 2008, and master in Biophysics (Master Proyect: Transcriptional Regulatory Network of Mycobacterium tuberculosis: Signaling and Functional Aspects), Universidad de Zaragoza 2010. I have been working on systems biology and bioinformatics in the Bioinformation Group of the Aragon Institute of Health Sciences, which is led by Dr. Marijuán.
Pedro C. Marijuán
Pedro C. Marijuán Engineer and Doctor in Cognitive Neuroscience (PhD Thesis on "Natural Intelligence", Universidad de Barcelona, 1989). During more than 20 years, the author has advanced research on the nature of information & communication, and on bio- logical intelligence, looking at both the molecular-cellular and organismic (brain) realms; he was co-founder with Michael Conrad of FIS (Foundations of Information Science); organizer and co-organizer of several international conferences in the FIS field and organizer of the International Cajal Conference.
Special Issue: Towards a New Science of Information